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KMID : 0545119980080020188
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Journal of Microbiology and Biotechnology
1998 Volume.8 No. 2 p.188 ~ p.190
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Penicillide, a Nonpeptide Calpain Inhibitor, Produced by Penicillium sp. F60760
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Chung, Myung Chul
Lee, Ho Jae/Chun, Hyo Kon/Kho, Yung Hee
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Abstract
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Penicillide, having a 5H,7H-dibenzo[b,g][1,5] dioxocin-5-one skeleton, was isolated from the culture broth of Penicillium sp. F60760 as a nonpeptide inhibitor of calpain, a calcium-activated papain-like protease. The IC_50 value for the effect of penicillide against m-calpahi was 7.1μM. However, penicillide did not inhibit papain at a concentration of 200μM. These results suggest that penicillide is a new class of nonpeptide calpain inhibitor having an eight membered lactone ring.
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